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PD-168077 maleate
CAS No. 630117-19-0
PD-168077 maleate ( —— )
产品货号. M22987 CAS No. 630117-19-0
PD-168077 maleate is a selective agonist of dopamine D4 receptor(Ki : 9 nM)PD-168077, a selective D4 dopamine receptor agonist, injected into the paraventricular nucleus of the hypothalamus on penile erection was studied in male rats.?PD-168077 (1-200 ng) induced penile erection in a dose-dependent manner.?
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥389 | 有现货 |
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| 5MG | ￥648 | 有现货 |
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| 10MG | ￥988 | 有现货 |
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| 25MG | ￥2066 | 有现货 |
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| 50MG | ￥3467 | 有现货 |
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| 100MG | ￥5176 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PD-168077 maleate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PD-168077 maleate is a selective agonist of dopamine D4 receptor(Ki : 9 nM)PD-168077, a selective D4 dopamine receptor agonist, injected into the paraventricular nucleus of the hypothalamus on penile erection was studied in male rats.?PD-168077 (1-200 ng) induced penile erection in a dose-dependent manner.?
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产品描述PD-168077 maleate is a selective agonist of dopamine D4 receptor(Ki : 9 nM)PD-168077, a selective D4 dopamine receptor agonist, injected into the paraventricular nucleus of the hypothalamus on penile erection was studied in male rats.?PD-168077 (1-200 ng) induced penile erection in a dose-dependent manner.?The minimal effective dose was 50 ng, while the maximal response was found with 200 ng of the compound, which increased penile erection episodes from 0.3+/-0.03 to 1.7+/-0.21.?The proerectile effect of PD-168077 was reduced almost completely by L-745,870 (3-(4-[chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-B]pyridine trihydrochloride), a selective D4 dopamine receptor antagonist, (1 microg) given into the paraventricular nucleus before the D4 dopamine agonist, and by other nonselective dopamine receptor antagonists, such as haloperidol (1 microg) and clozapine (1 microg), which block all dopamine receptor subtypes.?The pro-erectile effect of PD-168077 was also reduced by the NO synthase inhibitor NG-nitro-L-arginine methylester (25 microg), but not by the oxytocin receptor antagonist d(CH2)5Tyr(Me)2-Orn8-vasotocin (1 microg), when given into the paraventricular nucleus.?In spite of its inability to prevent the pro-erectile effect of PD-168077 when given in the paraventricular nucleus, d(CH2)5Tyr(Me)2-Orn8-vasotocin (1 microg) reduced almost completely PD-168077-induced penile erection when given into the lateral ventricles.?
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同义词——
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通路GPCR/G Protein
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靶点Dopamine Receptor
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受体D4
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研究领域——
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适应症——
化学信息
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CAS Number630117-19-0
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分子量450.49
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分子式C24H26N4O5
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纯度>98% (HPLC)
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溶解度DMSO:150 mg/mL (332.97 mM; Need ultrasonic)
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SMILESO=C(NCN1CCN(C2=CC=CC=C2C#N)CC1)C3=CC=CC(C)=C3.O=C(O)/C=C\C(O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Maria, Rosaria, Melis,et al. PD-168077, a selective dopamine D4 receptor agonist, induces penile erection when injected into the paraventricular nucleus of male rats[J]. Neuroscience Letters, 2005.
产品手册
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